Autophagy-mediated regulation patterns contribute to the alterations of the immune microenvironment in periodontitis.

ABSTRACT: The relationship between autophagy and immunity has been thoroughly investigated. However, little is known about the role of autophagy in shaping the immune-microenvironment of periodontitis. Thus, we aim to explore the impact of autophagy on the immune-microenvironment of periodontitis. The expression distinctions of autophagy genes between healthy and periodontitis samples have been investigated. The connections between autophagy and immune characteristics including infiltrating immunocyte, immune reaction and human leukocyte antigen (HLA) gene were evaluated. The distinct autophagy-mediated expression patterns were identified and immune characteristics under distinct patterns were revealed. Autophagy phenotype-related genes were identified. 16 autophagy genes were dysregulated and a ten

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7835039 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature