Integrated proteome and phosphoproteome analyses of peripheral blood mononuclear cells in primary Sjogren syndrome patients.

ABSTRACT: Primary Sjögren syndrome (pSS) is a common autoimmune disease. Here, we performed the first proteome and phosphoproteome analyses of peripheral blood mononuclear cells in pSS patients to obtain a comprehensive profile and identify the potential crucial proteins and pathways for the screening and evaluation of pSS patients. Peripheral blood mononuclear cells from 8 pSS-confirmed patients (American-European Consensus Group Criteria, 2002) and 10 normal controls were selected. Label-free quantitative proteomics was utilized to obtain quantitative information. In total, 787 proteins were identified as differentially expressed proteins, and 175 phosphosites on 123 proteins were identified as differentially phosphorylated proteins. We performed functional enrichment analyses with these proteins

SUBMITTER: Huang S 

PROVIDER: S-EPMC7835054 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature