Clinical impact of ¹⁸F-FDG-PET among memory clinic patients with uncertain diagnosis.

ABSTRACT:

Purpose

To assess the clinical impact and incremental diagnostic value of ¹⁸F-fluorodeoxyglucose (FDG-PET) among memory clinic patients with uncertain diagnosis.

Methods

The study population consisted of 277 patients who, despite extensive baseline cognitive assessment, MRI, and CSF analyses, had an uncertain diagnosis of mild cognitive impairment (MCI) (n = 177) or dementia (n = 100). After baseline diagnosis, each patient underwent an FDG-PET, followed by a post-FDG-PET diagnosis formulation. We evaluated (i) the change in diagnosis (baseline vs. post-FDG-PET), (ii) the change in diagnostic accuracy when comparing each baseline and post-FDG-PET diagnosis to a long-term follow-up (3.6 ± 1.8 years) diagnosis used as reference, and (iii) comparative FDG-PET perform

SUBMITTER: Perini G 

PROVIDER: S-EPMC7835147 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature