False positive PSMA PET for tumor remnants in the irradiated prostate and other interpretation pitfalls in a prospective multi-center trial.

ABSTRACT:

Purpose

Readers need to be informed about potential pitfalls of [⁶⁸Ga]Ga-PSMA-11 PET interpretation.

Methods

Here we report [⁶⁸Ga]Ga-PSMA-11 PET findings discordant with the histopathology/composite reference standard in a recently published prospective trial on 635 patients with biochemically recurrent prostate cancer.

Results

Consensus reads were false positive in 20 regions of 17/217 (8%) patients with lesion validation. Majority of the false positive interpretations (13 of 20, 65%) occurred in the context of suspected prostate (bed) relapse (T) after radiotherapy (n = 11); other false positive findings were noted for prostate bed post prostatectomy (T, n = 2), pelvic nodes (N, n = 2), or extra pelvic lesions (M, n = 5). Major sources of false

SUBMITTER: Fendler WP 

PROVIDER: S-EPMC7835157 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature