Prior therapies as prognostic factors of overall survival in metastatic castration-resistant prostate cancer patients treated with [¹⁷⁷Lu]Lu-PSMA-617. A WARMTH multicenter study (the 617 trial).

ABSTRACT:

Introduction

The impact of prior therapies, especially chemotherapy, on overall survival (OS) in patients with castration-resistant prostate cancer (CRPC) receiving [¹⁷⁷Lu]Lu-PSMA-617 therapy has been the subject of controversy. Therefore, WARMTH decided to plan a multicenter retrospective analysis (the "617 trial") to evaluate response rate and OS as well as the impact of prior therapies on OS in more than 300 patients treated with ¹⁷⁷Lu-PSMA-617.

Materials and methods

The data of 631 metastatic CRPC (mCRPC) patients from 11 different clinics were evaluated. According to the inclusion and exclusion criteria, all patients had to have received at least abiraterone or enzalutamide prior to [¹⁷⁷Lu]Lu-PSMA-617 therapy. The patients were divided i

SUBMITTER: Ahmadzadehfar H 

PROVIDER: S-EPMC7835179 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature