Tumour blood flow for prediction of human prostate cancer aggressiveness: a study with Rubidium-82 PET, MRI and Na⁺/K⁺-ATPase-density.

ABSTRACT:

Purpose

Tumour blood flow (TBF) is a crucial determinant of cancer growth. Recently, we validated Rubidium-82 (⁸²Rb) positron emission tomography (PET) for TBF measurement in prostate cancer (PCa) and found TBF and cancer aggressiveness positively correlated. The aims of the present study were to determine the ability of TBF for separating significant from insignificant PCa and to examine the relation to underlying Na⁺/K⁺-ATPase density, which is relevant as ⁸²Rb is transported intracellularly via the Na⁺/K⁺-ATPase.

Methods

One hundred and two patients were included for pelvic ⁸²Rb PET scan prior to magnetic resonance imaging (MRI)-guided prostate biopsy. Findings constituted 100 PCa lesions (86 pat

SUBMITTER: Jochumsen MR 

PROVIDER: S-EPMC7835182 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature