⁶⁸Ga-labelled desferrioxamine-B for bacterial infection imaging.

ABSTRACT:

Purpose

With the increase of especially hospital-acquired infections, timely and accurate diagnosis of bacterial infections is crucial for effective patient care. Molecular imaging has the potential for specific and sensitive detection of infections. Siderophores are iron-specific chelators recognized by specific bacterial transporters, representing one of few fundamental differences between bacterial and mammalian cells. Replacing iron by gallium-68 without loss of bioactivity is possible allowing molecular imaging by positron emission tomography (PET). Here, we report on the preclinical evaluation of the clinically used siderophore, desferrioxamine-B (Desferal®, DFO-B), radiolabelled with ⁶⁸Ga for imaging of bacterial infections.

Methods

In vitro characterizatio

SUBMITTER: Petrik M 

PROVIDER: S-EPMC7835195 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature