SCA-1 micro-heterogeneity in the fate decision of dystrophic fibro/adipogenic progenitors.

ABSTRACT: The term micro-heterogeneity refers to non-genetic cell to cell variability observed in a bell-shaped distribution of the expression of a trait within a population. The contribution of micro-heterogeneity to physiology and pathology remains largely uncharacterised. To address such an issue, we investigated the impact of heterogeneity in skeletal muscle fibro/adipogenic progenitors (FAPs) isolated from an animal model of Duchenne muscular dystrophy (DMD), the mdx mouse. FAPs play an essential role in muscle homoeostasis. However, in pathological conditions or ageing, they are the source of intramuscular infiltrations of fibrotic or adipose tissue. By applying a multiplex flow cytometry assay, we characterised and purified from mdx muscles two FAP cell states expressing different levels of S

SUBMITTER: Giuliani G 

PROVIDER: S-EPMC7835386 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature