Rationale and methods of a randomized trial evaluating the effect of neprilysin inhibition on left ventricular remodelling.

ABSTRACT:

Aims

In patients at high risk of heart failure following myocardial infarction (MI) as a result of residual left ventricular systolic dysfunction (LVSD), the angiotensin receptor neprilysin inhibitor sacubitril/valsartan may result in a greater attenuation of adverse left ventricular (LV) remodelling than renin angiotensin aldosterone system inhibition alone, due to increased levels of substrates for neprilysin with vasodilatory, anti-hypertrophic, anti-fibrotic, and sympatholytic effects.

Methods

We designed a randomized, double-blinded, active-comparator trial to examine the effect of sacubitril/valsartan to the current standard of care in reducing adverse LV remodelling in patients with asymptomatic LVSD following MI. Eligible patients were ≥3 months following MI, had an

SUBMITTER: Docherty KF 

PROVIDER: S-EPMC7835504 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature