Frequency and clinical impact of hyperkalaemia within a large, modern, real-world heart failure population.

ABSTRACT:

Aims

This analysis qualitatively describes the impact of hyperkalaemia (HK) and renin-angiotensin-aldosterone system inhibitor (RAASi) use on clinical outcomes in patients with heart failure (HF).

Methods and results

Patients were included if they were ≥18 years old; had a serum potassium result between 1 January 2003 and 3 December 2018; had ≥2 separate, non-urgent care or emergency department encounters; and had an HF diagnosis. Criteria were met by 52 253 patients; 48 333 had sufficient follow-up for analysis. Patients were stratified by the presence/absence of HK (serum potassium >5.0 mmol/L) (n = 31 619 and n = 20 634, respectively) and by baseline left ventricular ejection fraction (LVEF) ≤40% or >40%. Compared with patients without HK (no-HK), those with HK had signif

SUBMITTER: Muhlestein JB 

PROVIDER: S-EPMC7835576 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature