Reporting and interpretation of subgroup analyses in heart failure randomized controlled trials.

ABSTRACT:

Aims

This study aimed to investigate the reporting of subgroup analyses in heart failure (HF) randomized controlled trials (RCTs) and to determine the strength and credibility of subgroup claims.

Methods and results

All primary HF RCTs published in nine high-impact journals from 1 January 2008 to 31 December 2017 were included. Multivariable regression analysis was used to identify factors that may favour the reporting of results in specific subgroups. Strength of the subgroup effect claimed was classified into (i) strong, (ii) likely, or (iii) suggestive. Credibility of subgroup claim was scored using a pre-specified 10 pointer criteria. Of the 261 HF RCTs studied, 107 (41%) reported subgroup analyses. Twenty-five (23%) RCTs claimed a subgroup effect for the primary outcome

SUBMITTER: Khan MS 

PROVIDER: S-EPMC7835611 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature