Impaired cerebral oxygenation in heart failure patients at rest and during head-up tilt testing.

ABSTRACT:

Aims

Heart failure (HF) confers potentially negative effects on the brain and autonomic nervous system. The measurement cerebral tissue oxygen saturation (SctO₂ ) may aid in understanding such effects. We aimed to investigate if compensated HF affects SctO₂ at rest and during orthostatic challenge.

Methods and results

Non-invasive haemodynamic monitoring and near-infrared spectroscopy were applied during head-up tilt (HUT) in 61 HF patients [mean (SD) 71 (11) years, 82% male, New York Heart Association (NYHA) class I-III] and 60 controls [60 (12) years, 42% male). Group differences in continuous variables were compared using Student's t-test. Associations between HF and SctO₂ were studied using multivariable linear regression models adjusted

SUBMITTER: Kharraziha I 

PROVIDER: S-EPMC7835614 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature