Heart failure development in obesity: underlying risk factors and mechanistic pathways.

ABSTRACT:

Aims

People with obesity are at risk for developing heart failure (HF), but little is known about the mechanistic pathways that link obesity with cardiac dysfunction.

Methods and results

We included 2030 participants from the Swedish Obese Subjects study who received conventional obesity treatment. First-time detection of HF was obtained by cross-checking the study population with the Swedish National Patient Register and the Swedish Cause of Death Register. We also examined if atrial fibrillation and myocardial infarction as time-dependent variables could predict incident HF The mean age of the study cohort was 48.7 years, and 28% were men. The mean body mass index at baseline was 40.1 kg/m² and remained stable during a median follow-up of 20.1 years. First-time

SUBMITTER: Jamaly S 

PROVIDER: S-EPMC7835624 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature