Comprehensive plasma metabolites profiling reveals phosphatidylcholine species as potential predictors for cardiac resynchronization therapy response.

ABSTRACT:

Aims

This study aimed to identify the plasma metabolite fingerprint in patients with heart failure and to develop a prediction tool based on differential metabolites for predicting the response to cardiac resynchronization therapy (CRT).

Methods and results

We prospectively recruited 32 healthy individuals and 42 consecutive patients with HF who underwent CRT between January 2018 and January 2019. Peripheral venous blood samples, clinical data, and echocardiographic signatures were collected before CRT implantation. Liquid chromatography-mass spectrometry was used to perform untargeted metabolites profiling for peripheral plasma under ESI+ and ESI- modes. After 6 month follow-up, patients were categorized as CRT responders or non-responders based on the alterations of echoca

SUBMITTER: Yang S 

PROVIDER: S-EPMC7835628 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature