Molecular Diversity of Clinically Stable Human Kidney Allografts.

ABSTRACT:

Importance

Clinical decision and immunosuppression dosing in kidney transplantation rely on transplant biopsy tissue histology even though histology has low specificity, sensitivity, and reproducibility for rejection diagnosis. The inclusion of stable allografts in mechanistic and clinical studies is vital to provide a normal, noninjured comparative group for all interrogative studies on understanding allograft injury.

Objective

To refine the definition of a stable allograft as one that is clinically, histologically, and molecularly quiescent using publicly available transcriptomics data.

Design, setting, and participants

In this prognostic study, the National Center for Biotechnology Information Gene Expression Omnibus was used to search for microarray gene expressio

SUBMITTER: Rychkov D 

PROVIDER: S-EPMC7835722 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature