Human VAMP3 Suppresses or Negatively Regulates Bax Induced Apoptosis in Yeast.

ABSTRACT: Apoptosis is an essential process that is regulated genetically and could lead to a serious disease condition if not well controlled. Bax is one of the main proapoptotic proteins and actively involved in programmed cell death. It has been suggested that Bax induced apoptosis in yeast could be obstructed by enhancing vesicular membrane trafficking. Plasma membrane proteins and lipid oxidation were reduced by a vesicle-associated membrane protein (VAMP) when expressed in yeast, suggesting its potential role in repairing membranes. Membrane integrity is crucial, as the loss of membrane integrity will result in the leakage of ions from mitochondria, and ultimately cell death due to overproduction of reactive oxygen species (ROS). Expression of Arabidopsis' VAMP has been linked to antiapoptosis

SUBMITTER: Akintade DD 

PROVIDER: S-EPMC7835773 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature