Nanoplasmonic-Nanofluidic Single-Molecule Biosensors for Ultrasmall Sample Volumes.

ABSTRACT: Detection of small amounts of biological compounds is of ever-increasing importance but also remains an experimental challenge. In this context, plasmonic nanoparticles have emerged as strong contenders enabling label-free optical sensing with single-molecule resolution. However, the performance of a plasmonic single-molecule biosensor is not only dependent on its ability to detect a molecule but equally importantly on its efficiency to transport it to the binding site. Here, we present a theoretical study of the impact of downscaling fluidic structures decorated with plasmonic nanoparticles from conventional microfluidics to nanofluidics. We find that for ultrasmall picolitre sample volumes, nanofluidics enables unprecedented binding characteristics inaccessible with conventional microflu

SUBMITTER: Spackova B 

PROVIDER: S-EPMC7836060 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature