Effects of miR-672 on the angiogenesis of adipose-derived mesenchymal stem cells during bone regeneration.

ABSTRACT:

Background

Sufficient vascular network plays an important role in the repair of bone defects. Bone morphogenetic protein 2 (BMP2) being a key regulator of angiogenesis has attracted the attention of researchers. In addition, evidence has suggested that BMP2 coordinates with microRNAs (miRNAs) to form intracellular networks regulating mesenchymal stem cells (MSCs) angiogenesis. Elucidating the underlying mechanisms that are regulating adipose-derived mesenchymal stem cells (ADSCs) angiogenesis might provide more effective method to enhance bone regeneration.

Methods

We identified the specific miRNA in rat ADSCs during BMP2-induced angiogenesis and chose the most significant differentially expressed miRNA, miR-672. Three lentiviral system named Lenti-miR-672, Lenti-as-miR-672,

SUBMITTER: Chen M 

PROVIDER: S-EPMC7836178 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature