Transcriptomic markers in pediatric septic shock prognosis: an integrative analysis of gene expression profiles.

ABSTRACT: The goal of this study was to identify potential transcriptomic markers in pediatric septic shock prognosis by an integrative analysis of multiple public microarray datasets. Using the R software and bioconductor packages, we performed a statistical analysis to identify differentially expressed (DE) genes in pediatric septic shock non-survivors, and further performed functional interpretation (enrichment analysis and co-expression network construction) and classification quality evaluation of the DE genes identified. Four microarray datasets (3 training datasets and 1 testing dataset, 252 pediatric patients with septic shock in total) were collected for the integrative analysis. A total of 32 DE genes (18 upregulated genes; 14 downregulated genes) were identified in pediatric septic shock

SUBMITTER: Wang Q 

PROVIDER: S-EPMC7836399 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature