Lack of drug-induced post-retrieval amnesia for auditory fear memories in rats.

ABSTRACT:

Background

Long-term memory formation is generally assumed to involve the permanent storage of recently acquired memories, making them relatively insensitive to disruption, a process referred to as memory consolidation. However, when retrieved under specific circumstances, consolidated fear memories are thought to return to a labile state, thereby opening a window for modification (e.g., attenuation) of the memory. Several interventions during a critical time frame after this destabilization seem to be able to alter the retrieved memory, for example by pharmacologically interfering with the restabilization process, either by direct protein synthesis inhibition or indirectly, using drugs that can be safely administered in patients (e.g., propranolol). Here, we find that, contrary to

SUBMITTER: Luyten L 

PROVIDER: S-EPMC7836479 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature