Association of timing of gabapentinoid use with motor recovery after spinal cord injury.

ABSTRACT:

Objective

To explore the hypothesis that earlier administration of acute gabapentinoids is beneficial to motor recovery after spinal cord injury in humans.

Methods

This is an observational study using a cohort from the European Multi-Centre Study about Spinal Cord Injury. Patient charts were reviewed to extract information regarding the administration and timing of gabapentinoid anticonvulsants. The primary outcome measure was motor scores, as measured by the International Standards for Neurological Classification of Spinal Cord Injury, collected longitudinally in the first year after injury. Sensory scores (light touch and pinprick) and functional measures (Spinal Cord Independence Measure) were secondary outcomes. Linear mixed effects regression models included a drug-by-t

SUBMITTER: Warner FM 

PROVIDER: S-EPMC7836656 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature