Assessment of antiviral potencies of cannabinoids against SARS-CoV-2 using computational and in vitro approaches.

ABSTRACT: Effective treatment choices to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are limited because of the absence of effective target-based therapeutics. The main object of the current research was to estimate the antiviral activity of cannabinoids (CBDs) against the human coronavirus SARS-CoV-2. In the presented research work, we performed in silico and in vitro experiments to aid the sighting of lead CBDs for treating the viral infections of SARS-CoV-2. Virtual screening was carried out for interactions between 32 CBDs and the SARS-CoV-2 M^pro enzyme. Afterward, in vitro antiviral activity was carried out of five CBDs molecules against SARS-CoV-2. Interestingly, among them, two CBDs molecules namely Δ⁹ -tetrahydrocannabinol (IC₅₀ = 10.25 μ

SUBMITTER: Raj V 

PROVIDER: S-EPMC7836687 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature