Impact of reproduction number on the multiwave spreading dynamics of COVID-19 with temporary immunity: A mathematical model.

ABSTRACT:

Objectives

The recent discoveries of phylogenetically confirmed COVID-19 reinfection cases worldwide, together with studies suggesting that antibody titres decrease over time, raise the question of what course the epidemic trajectories may take if immunity were really to be temporary in a significant fraction of the population. The objective of this study is to obtain an answer for this important question.

Methods

We construct a ground-up delay differential equation model tailored to incorporate different types of immune response. We considered two immune responses: (a) short-lived immunity of all types, and (b) short-lived sterilizing immunity with durable severity-reducing immunity.

Results

Multiple wave solutions to the model are manifest for intermediate values of

SUBMITTER: Shayak B 

PROVIDER: S-EPMC7836705 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature