An investigation of rhinovirus infection on cellular uptake of poly (glycerol-adipate) nanoparticles.

ABSTRACT: Viral infections represent 44% of newly emerging infections, and as is shown by the COVID-19 outbreak constitute a major risk to human health and wellbeing. Although there are many efficient antiviral agents, they still have drawbacks such as development of virus resistance and accumulation within off-target organs. Encapsulation of antiviral agents into nanoparticles (NPs) has been shown to improve bioavailability, control release, and reduce side effects. However, there is little quantitative understanding of how the uptake of NPs into virally infected cells compares to uninfected cells. In this work, the uptake of fluorescently labeled polymer NPs was investigated in several models of rhinovirus (RV) infected cells. Different multiplicities of RV infections (MOI) and timings of NPs upta

SUBMITTER: Abo-Zeid Y 

PROVIDER: S-EPMC7836899 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature