Temperature Trajectory Subphenotypes Correlate With Immune Responses in Patients With Sepsis.

ABSTRACT:

Objectives

We recently found that distinct body temperature trajectories of infected patients correlated with survival. Understanding the relationship between the temperature trajectories and the host immune response to infection could allow us to immunophenotype patients at the bedside using temperature. The objective was to identify whether temperature trajectories have consistent associations with specific cytokine responses in two distinct cohorts of infected patients.

Design

Prospective observational study.

Setting

Large academic medical center between 2013 and 2019.

Subjects

Two cohorts of infected patients: 1) patients in the ICU with septic shock and 2) hospitalized patients with Staphylococcus aureus bacteremia.

Interventions

Clinical data (incl

SUBMITTER: Bhavani SV 

PROVIDER: S-EPMC7837282 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature