CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling.

ABSTRACT: Evolutionarily conserved signaling pathways are crucial for adjusting growth, reproduction, and cell maintenance in response to altered environmental conditions or energy balance. However, we have an incomplete understanding of the signaling networks and mechanistic changes that coordinate physiological changes across tissues. We found that loss of the cAMP response element-binding protein (CREB) transcription factor significantly slows Caenorhabditis elegans' reproductive decline, an early hallmark of aging in many animals. Our results indicate that CREB acts downstream of the transforming growth factor β (TGF-β) Sma/Mab pathway in the hypodermis to control reproductive aging, and that it does so by regulating a Hedgehog-related signaling factor, WRT-10. Overexpression of hypodermal wrt-1

SUBMITTER: Templeman NM 

PROVIDER: S-EPMC7837322 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature