The cytokine storm in COVID-19: Further advances in our understanding the role of specific chemokines involved.

ABSTRACT: SARS-COV-2 infection represents the greatest pandemic of the world, counting daily increasing number of subjects positive to the virus and, sadly, increasing number of deaths. Current studies reported that the cytokine/chemokine network is crucial in the onset and maintenance of the "cytokine storm", the event occurring in those patients in whom the progression of COVID-19 will progress, in most cases, to a very severe and potentially threatening disease. Detecting a possible "immune signature" in patients, as assessed by chemokines status in patients with COVID-19, could be helpful for individual risk stratification for developing a more or less severe clinical course of the disease. The present review is specifically aimed at overviewing current evidences provided by in vitro and in vivo

SUBMITTER: Coperchini F 

PROVIDER: S-EPMC7837329 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature