Lymphocyte reconstitution after DMF discontinuation in clinical trial and real-world patients with MS.

ABSTRACT:

Background

Delayed-release dimethyl fumarate (DMF) has demonstrated robust efficacy in treating patients with relapsing-remitting multiple sclerosis. Decreases in absolute lymphocyte count (ALC) are a well-known pharmacodynamic effect of DMF treatment, but lymphocyte recovery dynamics are not well characterized after discontinuation of DMF.

Methods

Data sources included the Biogen DMF integrated clinical trial data set, a retrospective US chart abstraction study, and data from MSBase. We assessed rate and time course of lymphocyte reconstitution after DMF discontinuation.

Results

The majority of patients who developed lymphopenia while treated with DMF and subsequently discontinued treatment experienced ALC reconstitution. The median time to reach ALC ≥0.8 × 10^9<

SUBMITTER: Chan A 

PROVIDER: S-EPMC7837440 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature