Genetic Diversity of Drug-Related Genes in Native Americans of the Brazilian Amazon.

ABSTRACT:

Introduction

The genetic admixture of the Brazilian population has considerable relevance to the implementation of the principles of pharmacogenomics (PGx), as it may compromise the extrapolation of data obtained in more homogeneous world populations.

Purpose

This study aims to investigate a panel of 117 polymorphisms in 35 pharmacogenes, which contains label recommendations or clinical evidence by international drug regulatory agencies, in Amazonian Native American populations, and compare the results obtained with continental population data from the 1000 Genomes Project Consortium.

Patients and methods

The study population is composed of 109 Native American individuals from three Brazilian Amazon groups. The genotyping of the PGx polymorphisms was performed by alle

SUBMITTER: Fernandes MR 

PROVIDER: S-EPMC7837547 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature