Data-driven reduction of dendritic morphologies with preserved dendro-somatic responses.

ABSTRACT: Dendrites shape information flow in neurons. Yet, there is little consensus on the level of spatial complexity at which they operate. Through carefully chosen parameter fits, solvable in the least-squares sense, we obtain accurate reduced compartmental models at any level of complexity. We show that (back-propagating) action potentials, Ca2+ spikes, and N-methyl-D-aspartate spikes can all be reproduced with few compartments. We also investigate whether afferent spatial connectivity motifs admit simplification by ablating targeted branches and grouping affected synapses onto the next proximal dendrite. We find that voltage in the remaining branches is reproduced if temporal conductance fluctuations stay below a limit that depends on the average difference in input resistance between the abl

SUBMITTER: Wybo WA 

PROVIDER: S-EPMC7837682 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature