Circulating Markers of Neutrophil Extracellular Traps Are of Prognostic Value in Patients With COVID-19.

ABSTRACT:

Objective

The full spectrum of coronavirus disease 2019 (COVID-19) infection ranges from asymptomatic to acute respiratory distress syndrome, characterized by hyperinflammation and thrombotic microangiopathy. The pathogenic mechanisms are poorly understood, but emerging evidence suggest that excessive neutrophil extracellular trap (NET) formation plays a key role in COVID-19 disease progression. Here, we evaluate if circulating markers of NETs are associated with COVID-19 disease severity and clinical outcome, as well as to markers of inflammation and in vivo coagulation and fibrinolysis. Approach and Results: One hundred six patients with COVID-19 with moderate to severe disease were enrolled shortly after hospital admission and followed for 4 months. Acute and convalescent plasma

SUBMITTER: Ng H 

PROVIDER: S-EPMC7837697 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature