Immunologic Clearance of a BK Virus-associated Metastatic Renal Allograft Carcinoma.

ABSTRACT:

Background

Metastatic carcinoma of a renal allograft is a rare but life threatening event with a difficult clinical management. Recent reports suggested a potential role of BK polyomavirus (BKPyV) in the development of urologic tract malignancies in kidney transplant recipients.

Methods

We investigated a kidney-pancreas female recipient with an history of BKPyV nephritis who developed a rapidly progressive and widely metastatic donor-derived renal carcinoma 9 years after transplantation.

Results

Histology and fluorescence in situ hybridization analysis revealed a donor-derived (XY tumor cells) collecting (Bellini) duct carcinoma. The presence of BKPyV oncogenic large tumor antigen was identified in large amount within the kidney tumor and the bowel metastases. Whole g

SUBMITTER: Meier RPH 

PROVIDER: S-EPMC7837753 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature