Impact of Subclinical Borderline Inflammation on Kidney Transplant Outcomes.

ABSTRACT:

Background

Surveillance biopsies permit early detection of subclinical inflammation before clinical dysfunction, but the impact of detecting early subclinical phenotypes remains unclear.

Methods

We conducted a single-center retrospective cohort study of 441 consecutive kidney transplant recipients between 2015 and 2018 with surveillance biopsies at 6 months post-transplant. We tested the hypothesis that early subclinical inflammation (subclinical borderline changes, T cell-mediated rejection, or microvascular injury) is associated with increased incidence of a composite endpoint including acute rejection and allograft failure.

Results

Using contemporaneous Banff criteria, we detected subclinical inflammation in 31%, with the majority (75%) having a subclinical borderl

SUBMITTER: Seifert ME 

PROVIDER: S-EPMC7837932 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature