The antimicrobial peptide YD attenuates inflammation via miR-155 targeting CASP12 during liver fibrosis.

ABSTRACT: The antimicrobial peptide APKGVQGPNG (named YD), a natural peptide originating from Bacillus amyloliquefaciens CBSYD1, exhibited excellent antibacterial and antioxidant properties in vitro. These characteristics are closely related to inflammatory responses which is the central trigger for liver fibrosis. However, the therapeutic effects of YD against hepatic fibrosis and the underlying mechanisms are rarely studied. In this study, we show that YD improved liver function and inhibited the progression of liver fibrosis by measuring the serum transaminase activity and the expression of α-smooth muscle actin and collagen I in carbon tetrachloride-induced mice. Then we found that YD inhibited the level of miR-155, which plays an important role in inflammation and liver fib

SUBMITTER: Yan Z 

PROVIDER: S-EPMC7838029 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature