Current Advances in Immunotherapy for Glioblastoma.

ABSTRACT:

Purpose of review

This review seeks to inform oncology clinicians and researchers about the development of novel immunotherapies for the treatment of glioblastoma. An enumeration of ongoing and recently completed clinical trials will be discussed with special attention given to current technologies implemented to overcome central nervous system-specific challenges including barriers to the peripheral immune system, impaired antigen presentation, and T cell dysfunction.

Recent findings

The success of immunotherapy in other solid cancers has served as a catalyst to explore its application in glioblastoma, which has limited response to other treatments. Recent developments include multi-antigen vaccines that seek to overcome the heterogeneity of glioblastoma, as well as immune

SUBMITTER: Mende AL 

PROVIDER: S-EPMC7838142 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature