A clinico-pathological and molecular analysis reveals differences between solitary (early and late-onset) and synchronous rectal cancer.

ABSTRACT: Rectal cancer (RC) appears to behave differently compared with colon cancer. We aimed to analyze existence of different subtypes of RC depending on distinct features (age of onset and the presence of synchronous primary malignant neoplasms). We compared the clinicopathological, familial and molecular features of three different populations diagnosed with RC (early-onset RC [EORC], late-onset RC, and synchronous RC [SRC]). Eighty-five RCs were identified and were evaluated according to their microsatellite instability, CpG Island Methylator Phenotype (CIMP) and chromosomal instability, as assessed by Next Generation Sequencing and microarray-based comparative genomic hybridization approaches. The results were subjected to cluster analysis. SRCs displayed the most specific characteristics in

SUBMITTER: Perea J 

PROVIDER: S-EPMC7838158 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature