Atorvastatin impairs liver mitochondrial function in obese Gottingen Minipigs but heart and skeletal muscle are not affected.

ABSTRACT: Statins lower the risk of cardiovascular events but have been associated with mitochondrial functional changes in a tissue-dependent manner. We investigated tissue-specific modifications of mitochondrial function in liver, heart and skeletal muscle mediated by chronic statin therapy in a Göttingen Minipig model. We hypothesized that statins enhance the mitochondrial function in heart but impair skeletal muscle and liver mitochondria. Mitochondrial respiratory capacities, citrate synthase activity, coenzyme Q10 concentrations and protein carbonyl content (PCC) were analyzed in samples of liver, heart and skeletal muscle from three groups of Göttingen Minipigs: a lean control group (CON, n = 6), an obese group (HFD, n = 7) and an obese group treated with atorvastatin for 28 weeks (HFD + ATO,

SUBMITTER: Christiansen LB 

PROVIDER: S-EPMC7838180 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature