Multi-Q 2 software facilitates isobaric labeling quantitation analysis with improved accuracy and coverage.

ABSTRACT: Mass spectrometry-based proteomics using isobaric labeling for multiplex quantitation has become a popular approach for proteomic studies. We present Multi-Q 2, an isobaric-labeling quantitation tool which can yield the largest quantitation coverage and improved quantitation accuracy compared to three state-of-the-art methods. Multi-Q 2 supports identification results from several popular proteomic data analysis platforms for quantitation, offering up to 12% improvement in quantitation coverage for accepting identification results from multiple search engines when compared with MaxQuant and PatternLab. It is equipped with various quantitation algorithms, including a ratio compression correction algorithm, and results in up to 336 algorithmic combinations. Systematic evaluation shows differ

SUBMITTER: Chen CT 

PROVIDER: S-EPMC7838301 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature