Neonatal antibiotic exposure impairs child growth during the first six years of life by perturbing intestinal microbial colonization.

ABSTRACT: Exposure to antibiotics in the first days of life is thought to affect various physiological aspects of neonatal development. Here, we investigate the long-term impact of antibiotic treatment in the neonatal period and early childhood on child growth in an unselected birth cohort of 12,422 children born at full term. We find significant attenuation of weight and height gain during the first 6 years of life after neonatal antibiotic exposure in boys, but not in girls, after adjusting for potential confounders. In contrast, antibiotic use after the neonatal period but during the first 6 years of life is associated with significantly higher body mass index throughout the study period in both boys and girls. Neonatal antibiotic exposure is associated with significant differences in the gut mic

SUBMITTER: Uzan-Yulzari A 

PROVIDER: S-EPMC7838415 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature