Nicotine Increases Spontaneous Glutamate Release in the Rostromedial Tegmental Nucleus.

ABSTRACT: The rostromedial tegmental nucleus (RMTg) is a bilateral structure localized in the brainstem and comprise of mainly GABAergic neurons. One of the main functions of the RMTg is to regulate the activity of dopamine neurons of the mesoaccumbens pathway. Therefore, the RMTg has been proposed as a modulator of the reward system and adaptive behaviors associated to reward learning. The RMTg receives an important glutamatergic input from the lateral habenula. Also, it receives cholinergic inputs from the laterodorsal and pedunculopontine tegmental nuclei. Previously, it was reported that nicotine increases glutamate release, evoked by electric stimulation, in the RMTg nucleus. However, the mechanisms by which nicotine induces this effect were not explored. In the present work, we performed elect

SUBMITTER: Castillo-Rolon D 

PROVIDER: S-EPMC7838497 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature