Antenatal Endotoxin Impairs Lung Mechanics and Increases Sensitivity to Ventilator-Induced Lung Injury in Newborn Rat Pups.

ABSTRACT: Perinatal inflammation due to chorioamnionitis and ventilator-induced lung injury (VILI) at birth is independent risk factors for the development of bronchopulmonary dysplasia (BPD). We have previously shown that antenatal endotoxin (ETX) causes abnormal lung structure and function in 2-week-old rats, but whether ETX impairs lung mechanics at birth and increases risk for VILI is unknown. Fetal rats were exposed to 10 μg endotoxin or saline via intra-amniotic injection. At birth (D0) or 7 days (D7), rats received 90 min of lung protective ventilation [PROTECT group; tidal volume (Vt) = 6 ml/kg with positive end expiratory pressure (PEEP) = 2 cmH₂O]; P20 ventilation [plateau pressure (Pplat) = 20 cmH₂O, PEEP = 0]; or P24 ventilation (Pplat = 24 cmH₂O,

SUBMITTER: Mandell EW 

PROVIDER: S-EPMC7838561 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature