Activation of p21 limits acute lung injury and induces early senescence after acid aspiration and mechanical ventilation.

ABSTRACT: The p53/p21 pathway is activated in response to cell stress. However, its role in acute lung injury has not been elucidated. Acute lung injury is associated with disruption of the alveolo-capillary barrier leading to acute respiratory distress syndrome (ARDS). Mechanical ventilation may be necessary to support gas exchange in patients with ARDS, however, high positive airway pressures can cause regional overdistension of alveolar units and aggravate lung injury. Here, we report that acute lung injury and alveolar overstretching activate the p53/p21 pathway to maintain homeostasis and avoid massive cell apoptosis. A systematic pooling of transcriptomic data from animal models of lung injury demonstrates the enrichment of specific p53- and p21-dependent gene signatures and a validated senesc

SUBMITTER: Blazquez-Prieto J 

PROVIDER: S-EPMC7838583 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature