Urine Nuclear Magnetic Resonance (NMR) Metabolomics in Age-Related Macular Degeneration.

ABSTRACT: Biofluid biomarkers of age-related macular degeneration (AMD) are still lacking, and their identification is challenging. Metabolomics is well-suited to address this need, and urine is a valuable accessible biofluid. This study aimed to characterize the urinary metabolomic signatures of patients with different stages of AMD and a control group (>50 years). It was a prospective, cross-sectional study, where subjects from two cohorts were included: 305 from Coimbra, Portugal (AMD patients n = 252; controls n = 53) and 194 from Boston, United States (AMD patients n = 147; controls n = 47). For all participants, we obtained color fundus photographs (for AMD staging) and fasting urine samples, which were analyzed using ¹H nuclear magnetic resonance (NMR) spectroscopy. Our results rev

SUBMITTER: Lains I 

PROVIDER: S-EPMC7838731 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature