The presence of Aspergillus fumigatus is associated with worse respiratory quality of life in cystic fibrosis.

ABSTRACT:

Background

The clinical effects of Aspergillus fumigatus in the cystic fibrosis (CF) airway, with the exception of allergic bronchopulmonary aspergillosis, is unclear.

Methods

CF adolescents and adults (age 14 years and older) underwent bacterial and semi-selective fungal culture testing to determine the prevalence of fungi in the CF respiratory tract and the independent association between the presence of Aspergillus fumigatus and clinical characteristics.

Results

Aspergillus fumigatus (10.3%) and Candida species (57.8%) were the most common filamentous fungi and yeast seen respectively in the sputa of 206 individuals with CF. Inhaled corticosteroid (ICS) use was more common in Aspergillus fumigatus-positive than Aspergillus fumigatusnegative (100% versus 75.8%, p = 

SUBMITTER: Hong G 

PROVIDER: S-EPMC7839066 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature