Opiate and Tobacco Use and Exposure to Carcinogens and Toxicants in the Golestan Cohort Study.

ABSTRACT:

Background

There is little information on human exposure to carcinogens and other toxicants related to opiate use, alone or in combination with tobacco.

Methods

Among male participants of the Golestan Cohort Study in Northeast Iran, we studied 28 never users of either opiates or tobacco, 33 exclusive cigarette smokers, 23 exclusive users of smoked opiates, and 30 opiate users who also smoked cigarettes (dual users; 21 smoked opiates and 9 ingested them). We quantified urinary concentrations of 39 exposure biomarkers, including tobacco alkaloids, tobacco-specific nitrosamines, polycyclic aromatic hydrocarbons (PAH), and volatile organic compounds (VOC), and used decomposition to parse out the share of the biomarker concentrations explained by opiate use and nicotine dose.

SUBMITTER: Etemadi A 

PROVIDER: S-EPMC7839071 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature