Identification of differentially methylated genes as diagnostic and prognostic biomarkers of breast cancer.

ABSTRACT:

Background

Aberrant DNA methylation is significantly associated with breast cancer.

Methods

In this study, we aimed to determine novel methylation biomarkers using a bioinformatics analysis approach that could have clinical value for breast cancer diagnosis and prognosis. Firstly, differentially methylated DNA patterns were detected in breast cancer samples by comparing publicly available datasets (GSE72245 and GSE88883). Methylation levels in 7 selected methylation biomarkers were also estimated using the online tool UALCAN. Next, we evaluated the diagnostic value of these selected biomarkers in two independent cohorts, as well as in two mixed cohorts, through ROC curve analysis. Finally, prognostic value of the selected methylation biomarkers was evaluated breast cancer by

SUBMITTER: Mao XH 

PROVIDER: S-EPMC7839189 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature