Changes in inflammatory factors in the Brown Norway rat model of food allergy.

ABSTRACT:

Background

The role of serum S100A8/A9 in intestinal inflammation has been confirmed, and its role in food allergy is currently being investigated.

Objective

To explore the levels of S100A8/A9 and inflammatory factors, including Toll-like receptors 4 (TLR4), Nuclear transcription factors (NF-κB) and Tumor necrosis factor α (TNF-α), in mild food allergies.

Methods

Eighty 3-week-old male Brown Norway rats were used. Forty rats were randomly assigned to the ovalbumin-sensitized experimental group, while 40 rats were assigned to the normal saline sham-sensitized control group. Body weight and length and the levels of serum ovalbumin-specific IgE (OVA-IgE), histamine, Th1-associated and Th2-associated factors, S100A8/A9 and inflammation-associated cytokines were compared.<

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC7839196 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature