Profile of copper-associated DNA methylation and its association with incident acute coronary syndrome.

ABSTRACT:

Background

Acute coronary syndrome (ACS) is a cardiac emergency with high mortality. Exposure to high copper (Cu) concentration has been linked to ACS. However, whether DNA methylation contributes to the association between Cu and ACS is unclear.

Methods

We measured methylation level at > 485,000 cytosine-phosphoguanine sites (CpGs) of blood leukocytes using Human Methylation 450 Bead Chip and conducted a genome-wide meta-analysis of plasma Cu in a total of 1243 Chinese individuals. For plasma Cu-related CpGs, we evaluated their associations with the expression of nearby genes as well as major cardiovascular risk factors. Furthermore, we examined their longitudinal associations with incident ACS in the nested case-control study.

Results

We identified four novel Cu-ass

SUBMITTER: Long P 

PROVIDER: S-EPMC7839231 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature