Dataset Information

Blocking integrin α₄β₇-mediated CD4 T cell recruitment to the intestine and liver protects mice from western diet-induced non-alcoholic steatohepatitis.

ABSTRACT:

Background & aims

The heterodimeric integrin receptor α₄β₇ regulates CD4 T cell recruitment to inflamed tissues, but its role in the pathogenesis of non-alcoholic steatohepatitis (NASH) is unknown. Herein, we examined the role of α₄β₇-mediated recruitment of CD4 T cells to the intestine and liver in NASH.

Methods

Male littermate F11r^+/+ (control) and junctional adhesion molecule A knockout F11r^-/- mice were fed a normal diet or a western diet (WD) for 8 weeks. Liver and intestinal tissues were analyzed by histology, quantitative reverse transcription PCR (qRT-PCR), 16s rRNA sequencing and flow cytometry. Colonic mucosa-associated microbiota were analyzed using 16s rRNA sequencing. Liver biopsies from patients

SUBMITTER: Rai RP

PROVIDER: S-EPMC7839272 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Dataset Information

Blocking integrin α₄β₇-mediated CD4 T cell recruitment to the intestine and liver protects mice from western diet-induced non-alcoholic steatohepatitis.

Background & aims

Methods

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Blocking integrin α4β7-mediated CD4 T cell recruitment to the intestine and liver protects mice from western diet-induced non-alcoholic steatohepatitis.

Background & aims

Methods

OmicsDI is part of the ELIXIR infrastructure

Tweets

Blocking integrin α₄β₇-mediated CD4 T cell recruitment to the intestine and liver protects mice from western diet-induced non-alcoholic steatohepatitis.