Antigen density dictates RBC clearance, but not antigen modulation, following incompatible RBC transfusion in mice.

ABSTRACT: Incompatible red blood cell (RBC) transfusion can result in life-threatening transfusion complications that can be challenging to manage in patients with transfusion-dependent anemia. However, not all incompatible RBC transfusions result in significant RBC removal. One factor that may regulate the outcome of incompatible RBC transfusion is the density of the incompatible antigen. Despite the potential influence of target antigen levels during incompatible RBC transfusion, a model system capable of defining the role of antigen density in this process has not been developed. In this study, we describe a novel model system of incompatible transfusion using donor mice that express different levels of the KEL antigen and recipients with varying anti-KEL antibody concentrations. Transfusion of K

SUBMITTER: Arthur CM 

PROVIDER: S-EPMC7839377 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature